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KMID : 0043320080310091108
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Archives of Pharmacal Research
2008 Volume.31 No. 9 p.1108 ~ p.1114
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GPR12 Selections of the Metabolites from an Endophytic Streptomyces sp. Asociated with Cistanches deserticola
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Lin Zhen-Jian
Zhu Wei-Ming
Gu Qian-Qun
Fang Yu-chun
Zhu Tian-jiao
Lu Xiao-Ming
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Abstract
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An endophytic Streptomyces sp. (AC-2) was isolated from the root of Cistanches deserticola Y.C.Ma..Chemical investigations of the culture broth of AC-2 afforded fifteen compounds including K1115 A (1), tyrosol (2), phenylethylamine derivatives (3, 4), cyclic dipeptides (5-8), nucleosides and their aglycones (9-13), N-acetyltryptamine (14), and pyrrole-2-carboxylic acid (15). Only tyrosol can promote an increase of intracellular cAMP special on GPR12 transfected cells, such as CHO and HEK293, which means it may be a possible ligand for GPR12.
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KEYWORD
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Cistanches deserticola, Endophyte, Streptomyces, Cyclopeptide, Nucleoside, cAMP, GPR12
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